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Review
. 2013 Oct 1;18(4):465-9.
doi: 10.1016/j.cmet.2013.08.002. Epub 2013 Aug 22.

A Central role for mTOR in lipid homeostasis

Dudley W Lamming  1 , David M Sabatini
Affiliations
Review

A Central role for mTOR in lipid homeostasis

Dudley W Lamming et al. Cell Metab. .

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.

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Figures

Figure 1
Figure 1
mTOR in lipid homeostasis. A) A model of the actions of mTORC1 and mTORC2 in lipid metabolism, including adipogenesis, lipogenesis and lipolysis. mTORC1 also controls ketogenesis, which may have a reciprocal relationship with lipogenesis, via NCoR1, but the exact mechanism by which it regulates NCoR1 is unknown. The mechanism by which mTORC2 regulates lipogenesis and lipolysis are likewise not currently known, although Akt may be involved in the regulation of lipogenesis. B) Representative Oil-Red-O stained liver sections from wild-type or Rictor Liver knockout (L-RicKO) mice on a high-fat diet for 25 weeks.
See this image and copyright information in PMC

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