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. 2013 Dec:91:21-27.
doi: 10.1016/j.fitote.2013.08.013. Epub 2013 Aug 23.

Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort

Jian Huang  1 , Xiao-Qing Lu  1 , Cui Zhang  1 , Jin Lu  1 , Guo-Yu Li  2 , Rui-Chao Lin  3 , Jin-Hui Wang  4
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Anti-inflammatory ligustilides from Ligusticum chuanxiong Hort

Jian Huang et al. Fitoterapia. 2013 Dec.

Abstract

Four new ligustilides chuanxiongnolide R1 (1), chuanxiongnolide R2 (2), chuanxiongdiolide R1 (3) and chuanxiongdiolide R2 (4) together with eight known derivatives (5-12) were isolated from the root of Ligusticum chuanxiong Hort. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were confirmed via the circular dichroism (CD) spectrum. The anti-inflammatory assay in LPS-triggered RAW 264.7 macrophages was carried out on the twelve compounds. 1, 3, 5 and 6 showed significant inhibitory effects against LPS-induced NO production.

Keywords: Anti-inflammatory activity; CD; Ligusticum chuanxiong Hort; Ligustilide.

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