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. 2013 Dec;37(12):2437-42.
doi: 10.1007/s00264-013-2055-6. Epub 2013 Aug 24.

Primary lymphoma of bone: outcome and role of surgery

Guido Scoccianti  1 , Luigi Rigacci, Benedetta Puccini, Domenico Andrea Campanacci, Gabriele Simontacchi, Alberto Bosi, Rodolfo Capanna
Affiliations

Primary lymphoma of bone: outcome and role of surgery

Guido Scoccianti et al. Int Orthop. 2013 Dec.

Abstract

Purpose: Primary bone lymphoma is a rare disease. Little is reported about surgical procedures in these patients. We evaluated a single-centre consecutive series of 21 patients for results, prognostic factors and surgical treatment.

Methods: Patient ages ranged from 19 to 82 years. The most frequently affected site was the spine (six cases), followed by the ileum, femur and mandible (three cases each). Four patients were treated with chemotherapy and 17 with chemotherapy and radiation therapy. Six patients were affected by a pathological fracture. Surgery was performed in four patients (19%), in two cases before chemotherapy, in one case during chemotherapy and in one case after chemotherapy and radiotherapy. Five patients died within the range of three to 36 months after diagnosis. Average follow-up of the remaining patients was 62.8 (19-145) months.

Results: Overall survival was 74.2% at five years. The only positive prognostic factor was complete remission after chemotherapy. A trend for better survival was present for International Prognostic Index (IPI) score (P = 0.051), under 40 years of age (P = 0.10) and abnormal lactate dehydrogenase (LDH) values (P = 0.10), but it did not reach statistical significance.

Conclusions: Surgical treatment should be aimed at restoring function and eliminating pain while minimising delays in the chemotherapy schedule. When feasible, postponing surgery until after chemotherapy is advisable.

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Figures

Fig. 1
Fig. 1
A 23-year-old woman with primary bone lymphoma affecting the right proximal humerus: a coronal magnetic resonance imaging (MRI) view at presentation; b coronal MRI after chemotherapy and radiotherapy; c X-ray after chemotherapy and radiotherapy; d resection and reconstruction with prosthesis were performed
Fig. 2
Fig. 2
A 54-year-old man with primary bone lymphoma affecting the right tibia: a magnetic resonance imaging (MRI); b a few days after biopsy, a pathological fracture occurred; c before beginning chemotherapy and radiotherapy, the fracture was fixed with a plate without curettage of the involved bone; d fracture completely healed and the patient was disease free at 78 months
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References

    1. Freeman C. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29:252–260. doi: 10.1002/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#. - DOI - PubMed
    1. Rudders RA. Primary extranodal lymphoma: response to treatment and factors influencing prognosis. Cancer. 1978;42:406–416. doi: 10.1002/1097-0142(197808)42:2<406::AID-CNCR2820420205>3.0.CO;2-H. - DOI - PubMed
    1. Ostrowski ML, Unni KK, Banks PM, et al. Malignant lymphoma of bone. Cancer. 1986;58:2646–2655. doi: 10.1002/1097-0142(19861215)58:12<2646::AID-CNCR2820581217>3.0.CO;2-U. - DOI - PubMed
    1. Gianelli U, Patriarca C, Moro A, et al. Lymphomas of the bone: a pathological and clinical study of 54 cases. Int J Surg Pathol. 2002;10:257–266. doi: 10.1177/106689690201000403. - DOI - PubMed
    1. Alencar A, Pitcher D, Byrne G, Lossos IS. Primary bone lymphoma – the University of Miami experience. Leuk Lymphoma. 2010;51:39–49. doi: 10.3109/10428190903308007. - DOI - PubMed

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