Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct;32(10):1354-8.
doi: 10.1097/ICO.0b013e31829e3c80.

Epidemiology of Ocular Surface Squamous Neoplasia in a Veterans Affairs Population

Andrew J McClellan  1 , Allison L McClellan, Candido F Pezon, Carol L Karp, William Feuer, Anat Galor
Affiliations

Epidemiology of Ocular Surface Squamous Neoplasia in a Veterans Affairs Population

Andrew J McClellan et al. Cornea. 2013 Oct.

Abstract

Purpose: To evaluate the epidemiology of ocular surface squamous neoplasia (OSSN) and its associated risk factors in a South Florida Veterans Affairs Hospital population.

Methods: Retrospective case-control study. Twenty-eight confirmed cases of OSSN from 24,179 veterans who received care at the Miami Veterans Affairs Healthcare System and affiliated satellite eye clinics between March 1, 2007, and March 1, 2012. Data extracted from the veterans administration database that comprised demographic information and medical diagnosis information [based on International Classification of Disease (ICD-9) codes]. The main outcome measures were the period prevalence of OSSN and identification of factors associated with the presence of disease.

Results: The period prevalence of OSSN in our population was 0.1%. The risk factors studied included UV-related dermatologic diseases (melanoma, squamous and basal cell cancer, and actinic keratosis), UV-related ocular conditions (pterygium), HIV seropositivity, human papilloma virus-related diseases, and tobacco use. The presence of skin malignancy (squamous cell carcinoma and/or basal cell carcinoma) and pterygium was found to be significantly associated with the presence of OSSN [odds ratio, 4.40; 95% confidence interval, 2.03-9.55; P < 0.0005 and odds ratio, 16.2; 95% confidence interval, 7.11-36.9; P < 0.0005, respectively].

Conclusions: The presence of neoplasias and ocular conditions related to sun exposure was the most important risk factor for the occurrence of OSSN in a South Florida Veterans Affairs Healthcare System population consistent with previous epidemiological reports worldwide.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: No author has a conflict of interest to disclose.

References

    1. Basti S, Macsai MS. Ocular surface squamous neoplasia: a review. Cornea. 2003;22:687–704. - PubMed
    1. McDonnell JM, McDonnell PJ, Sun YY. Human papillomavirus DNA in tissues and ocular surface swabs of patients with conjunctival epithelial neoplasia. Invest Ophthalmol Vis Sci. 1992;33:184–189. - PubMed
    1. Rudkin AK, Dodd T, Muecke JS. The differential diagnosis of localised amelanotic limbal lesions: a review of 162 consecutive excisions. Br J Ophthalmol. 2011;95:350–354. - PubMed
    1. Tulvatana W, Bhattarakosol P, Sansopha L, et al. Risk factors for conjunctival squamous cell neoplasia: a matched case-control study. Br J Ophthalmol. 2003;87:396–398. - PMC - PubMed
    1. Kiire CA, Dhillon B. The aetiology and associations of conjunctival intraepithelial neoplasia. Br J Ophthalmol. 2006;90:109–113. - PMC - PubMed

Publication types