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Review
. 2013 Nov;54(11):2946-9.
doi: 10.1194/jlr.R043414. Epub 2013 Aug 23.

In celebration of the 100th anniversary of the lipid hypothesis of atherosclerosis

Daniel Steinberg  1
Affiliations
Review

In celebration of the 100th anniversary of the lipid hypothesis of atherosclerosis

Daniel Steinberg. J Lipid Res. 2013 Nov.

Abstract

This year marks the 100th anniversary of the publication of Anitschkow's classic paper proposing the central role of hypercholesterolemia in atherogenesis. We at the Journal of Lipid Research take this occasion to acknowledge the debt we all owe to Anitschkow and his colleagues for getting us on the right track. As discussed below in detail, his contributions were insightful and went well beyond simply pinpointing hypercholesterolemia as a major etiologic factor. Anitschkow's work led him to define most of the key elements in the initiation and evolution of lesions in animal models of atherogenesis.

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Figures

Fig. 1.
Fig. 1.
Title page of the classic 1913 Anitschkow and Chalatow paper.
Fig. 2.
Fig. 2.
Anitschkow shortly after his retirement.
See this image and copyright information in PMC

References

    1. Anitschkow N. N., Chalatow S. 1913. Ueber experimentelle Cholesterinsteatose und ihre Bedeutung fur die Entstehung einiger pathologischer Prozesse. Zentralbl. Allg. Pathol. 24: 1–9
    1. [No authors listed]. 1983. Classics in arteriosclerosis research: On experimental cholesterin steatosis and its significance in the origin of some pathological processes by N. Anitschkow and S. Chalatow, translated by Mary Z. Pelias, 1913. Arteriosclerosis. 3: 178–182 - PubMed
    1. Anitschkow N. N. 1933. Experimental atherosclerosis in animals. In Arteriosclerosis. E. V. Cowdry, editor. Macmillan, New York. 271–322.
    1. [No authors listed]. 1984. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. 251: 365–374. - PubMed
    1. [No authors listed]. 1984. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA. 251: 351–364. - PubMed