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Meta-Analysis
. 2013 Aug 16;8(8):e72487.
doi: 10.1371/journal.pone.0072487. eCollection 2013.

Assessing interactions between the association of common genetic variant at 1p11 (rs11249433) and hormone receptor status with breast cancer risk

Qian Chen  1 , Rongliang Shi, Weiyan Liu, Daowen Jiang
Affiliations
Meta-Analysis

Assessing interactions between the association of common genetic variant at 1p11 (rs11249433) and hormone receptor status with breast cancer risk

Qian Chen et al. PLoS One. .

Abstract

Background: The association between rs11249433 polymorphism on 1p11 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach. However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the 1p11-rs11249433 polymorphism and BC.

Methods: Databases including Pubmed, SCOPUS, ISI web of knowledge, Embase and Cochrane databases were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.

Results: A total of 15 articles involving 90,291 cases and 137,525 controls were included. In a combined analysis, the summary per-allele odds ratio (OR) for BC of 1p11-rs11249433 polymorphism was 1.09 (95% CI: 1.06-1.12; P<10(-5)). Significant associations were also observed under dominant and recessive genetic models. In the subgroup analysis by ethnicity, significantly increased risks were found in Caucasians; whereas no significant associations were found among Asians and Africans. In addition, our data indicate that 1p11-rs11249433 polymorphism is involved in BC susceptibility and confer its effect primarily in estrogen receptor-positive and progesterone receptor-positive tumors.

Conclusions: In conclusion, this meta-analysis demonstrated that the G allele of 1p11-rs11249433 is a risk factor associated with increased breast cancer susceptibility, but these associations vary in different ethnic populations.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Forest plot for association of 1p11-rs11249433 polymorphism and BC risk.
Figure 2
Figure 2. Per-allele odds ratios and 95% confidence intervals for the association between 1p11-rs11249433 and BC risk by ER status.
Figure 3
Figure 3. Per-allele odds ratios and 95% confidence intervals for the association between 1p11-rs11249433 and BC risk by PR status.
See this image and copyright information in PMC

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