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Meta-Analysis
. 2013 Aug 15;8(8):e72526.
doi: 10.1371/journal.pone.0072526. eCollection 2013.

Association between 1p11-rs11249433 polymorphism and breast cancer susceptibility: evidence from 15 case-control studies

Sheng Wu  1 , Jungang Cai, Hong Wang, Hongwei Zhang, Weige Yang
Affiliations
Meta-Analysis

Association between 1p11-rs11249433 polymorphism and breast cancer susceptibility: evidence from 15 case-control studies

Sheng Wu et al. PLoS One. .

Abstract

Genome-wide association studies have identified SNP rs11249433 at chromosome 1p11 as a new breast cancer (BC) susceptibility locus in populations of European descent. Since then, the relationship between 1p11- rs11249433 and breast cancer has been reported in various ethnic groups; however, these studies have yielded inconsistent results. To investigate this inconsistency, we performed a meta-analysis of 15 studies involving a total of 90,154 cases and 137,238 controls for 1p11-rs11249433 polymorphism to evaluate its effect on genetic susceptibility for breast cancer. An overall random effects odds ratio of 1.09 (95% CI: 1.06-1.12, P<10(-5)) was found for rs11249433-G variant. Significant results were also observed for heterozygous (OR=1.09, 95% CI: 1.05-1.12, P<10(-5)) and homozygote (OR=1.14, 95% CI: 1.08-1.21, P<10(-5)). There was strong evidence of heterogeneity, which largely disappeared after stratification by ethnicity. After stratified by ethnicity, significant associations were found among Caucasians. However, no significant associations were detected among East Asian and African populations. In addition, we found that rs11249433 polymorphism on 1p11 confer risk, exclusively for ER-positive tumors with per-allele OR of 1.13 (95% CI: 1.08-1.18; P <10(-5)) compared to ER-negative tumors of 1.01 (95% CI: 0.98-1.04; P=0.49). Similar results were also observed when stratified by PR status. Our findings demonstrated that rs11249433-G allele is a risk-conferring factor for the development of breast cancer, especially in Caucasians.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Frequencies of the risk allele of 1p11-rs11249433 polymorphism among controls stratified by ethnicity.
Figure 2
Figure 2. Forest plot for association of 1p11-rs11249433 polymorphism and BC risk.
Figure 3
Figure 3. Per-allele odds ratios and 95% confidence intervals for the association between 1p11-rs11249433 and BC risk by ER status.
See this image and copyright information in PMC

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