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. 2013 Jan;2(1):73-82.
doi: 10.3978/j.issn.2225-319X.2012.12.01.

Genes in thoracic aortic aneurysms/dissections - do they matter?

Julie De Backer  1 , Laurence Campens, Anne De Paepe
Affiliations

Genes in thoracic aortic aneurysms/dissections - do they matter?

Julie De Backer et al. Ann Cardiothorac Surg. 2013 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Vascular involvement in Loeys-Dietz patients (A&B) and an aneurysm-osteoarthritis patient (C). A. MRA reconstruction of the aorta in a patient with Loeys-Dietz syndrome. Note the dilated ascending aorta distal to the aortic root prosthesis that was previously inserted (arrow), the tortuous aorta and the tortuous and ectatic iliac and head & neck arteries; B. MRA reconstruction of the intracerebral vessels of a 8 year old boy with Loeys-Dietz syndrome. Note the markedly tortuous vessels; C. CT angiographic picture of bilateral Iliac Artery aneurysms in a patient with aneurysm-osteoarthritis syndrome
Figure 2
Figure 2
Flow chart illustrating the clinical and genetic work-up of patients with TAAD. NGS, Next Generation Sequencing; FTAA, familial thoracic aortic aneurysm; TAA, thoracic aortic aneurysms
Figure 3
Figure 3
The TGFβ pathway and related vasculopathies. Following its release from the Extracellular Matrix, TGFβ binds to its type II cell surface receptor (TβRII), which recruits and phosphorylates the type I receptor (TβRI). TβRI then recruits and phosphorylates SMAD2 and/or SMAD3. These P-SMADs then bind to the common SMAD (co-SMAD) SMAD4 to form a heterodimeric complex. This complex enters the cell nucleus where it acts as a transcription factor for various TGFβ-dependent genes, such as connective tissue growth factor (CTGF), plasminogen activator inhibitor-1 (PAI-1) and multiple collagens
See this image and copyright information in PMC

References

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