A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank
- PMID: 23978324
- PMCID: PMC3933464
- DOI: 10.1016/j.jalz.2013.06.003
A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank
Abstract
Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein deposits in the central nervous system (CNS), and only neuropathological examination enables a definitive diagnosis. Brain banks and their associated scientific programs have shaped the actual knowledge of NDs, identifying and characterizing the CNS deposits that define new diseases, formulating staging schemes, and establishing correlations between neuropathological changes and clinical features. However, brain banks have evolved to accommodate the banking of biofluids as well as DNA and RNA samples. Moreover, the value of biobanks is greatly enhanced if they link all the multidimensional clinical and laboratory information of each case, which is accomplished, optimally, using systematic and standardized operating procedures, and in the framework of multidisciplinary teams with the support of a flexible and user-friendly database system that facilitates the sharing of information of all the teams in the network. We describe a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania.
Keywords: Alzheimer's Disease; Autopsy; Cerebrospinal fluid; Dementia; Frontotemporal lobar degeneration; Genetics; Neurodegeneration; Parkinson's Disease; Plasma; Serum.
Copyright © 2014 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Figures

References
-
- Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006;314:130–3. - PubMed
-
- Alzheimer A. Über eine eigenartige Erkrankung der Hirnrinde. Allgemeine Z Psychiatrie Psychisch-Gerichtliche Med. 1907;64:146–8.
Further readings
-
- Henchcliffe C, Dodel R, Beal MF. Biomarkers of Parkinson’s disease and dementia with Lewy bodies. Prog Neurobiol. 2011;95:601–13. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01 NS044266/NS/NINDS NIH HHS/United States
- P30 AG010124/AG/NIA NIH HHS/United States
- AG10124/AG/NIA NIH HHS/United States
- K08 AG039510/AG/NIA NIH HHS/United States
- P50 NS053488/NS/NINDS NIH HHS/United States
- AG17586/AG/NIA NIH HHS/United States
- AG033101/AG/NIA NIH HHS/United States
- K08 AG033101/AG/NIA NIH HHS/United States
- U01 NS082134/NS/NINDS NIH HHS/United States
- R01 AG015116/AG/NIA NIH HHS/United States
- NS053488/NS/NINDS NIH HHS/United States
- NS44266/NS/NINDS NIH HHS/United States
- P01 AG017586/AG/NIA NIH HHS/United States
- T32 AG000255/AG/NIA NIH HHS/United States
- AG15116/AG/NIA NIH HHS/United States
- K23 NS088341/NS/NINDS NIH HHS/United States
- AG39510/AG/NIA NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical