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Comment
. 2013 Nov;23(11):1242-3.
doi: 10.1038/cr.2013.117. Epub 2013 Aug 27.

Liver in a dish

Qiurong Ding  1 , Chad A Cowan
Affiliations
Comment

Liver in a dish

Qiurong Ding et al. Cell Res. 2013 Nov.

Abstract

There exists a worldwide shortage of donor livers for transplant. This may not pose a problem in the future, as Takebe et al. have recently grown functional "liver buds" from stem cells in a dish.

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Figures

Figure 1
Figure 1
This figure outlines the strategy of generating organs from patients' iPSCs as an alternative to transplantation. Patient-derived pluripotent stem cells (iPSCs) can be differentiated in vitro to desired cell types. As demonstrated by Takebe et al., different cell types can be co-cultured in dish to recapitulate the earliest process of organogenesis and form three-dimensional organ buds. These in vitro produced organ buds could be used for transplantation in the future.
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Comment on

References

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