Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Oct;33(20):3974-5.
doi: 10.1128/MCB.01033-13. Epub 2013 Aug 26.

Histone methylation keeps the brakes on autophagy

Patrick L Collins  1 , Eugene M Oltz
Affiliations
Comment

Histone methylation keeps the brakes on autophagy

Patrick L Collins et al. Mol Cell Biol. 2013 Oct.
No abstract available

PubMed Disclaimer

Figures

Fig 1
Fig 1
Repression of autophagosome formation by G9a. Under resting, nutrient-rich conditions (left), G9a represses autophagosome genes LC3B, DOR, and WIPI1 by modifying the chromatin around gene promoters with the repressive H3K9me2 mark. In the cytoplasm, mTORC1 kinase phosphorylates and inactivates complexes containing ULK1 that drive autophagosome formation. Upon starvation or during T cell proliferation (right), G9a and H3K9me2 are removed from relevant promoters, leading to expression of LCB3, DOR, and WIPI1, which are essential components of autophagosomes. This transcription-dependent process synergizes with inactivation of mTORC1, which releases restrictions on ULK1 complexes and guides autophagic flux to its completion.
See this image and copyright information in PMC

Comment on

  • Epigenetic regulation of autophagy by the methyltransferase G9a.
    Artal-Martinez de Narvajas A, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujanda L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD. Artal-Martinez de Narvajas A, et al. Mol Cell Biol. 2013 Oct;33(20):3983-93. doi: 10.1128/MCB.00813-13. Epub 2013 Aug 5. Mol Cell Biol. 2013. PMID: 23918802 Free PMC article.

References

    1. Tachibana M, Ueda J, Fukuda M, Takeda N, Ohta T, Iwanari H, Sakihama T, Kodama T, Hamakubo T, Shinkai Y. 2005. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 9:815–826 - PMC - PubMed
    1. Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y. 2002. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16:1779–1791 - PMC - PubMed
    1. Chen X, El Gazzar M, Yoza BK, McCall CE. 2009. The NF-κB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J. Biol. Chem. 284:27857–27865 - PMC - PubMed
    1. Kondo Y, Shen L, Suzuki S, Kurokawa T, Masuko K, Tanaka Y, Kato H, Mizuno Y, Yokoe M, Sugauchi F, Hirashima N, Orito E, Osada H, Ueda R, Guo Y, Chen X, Issa J-PJ, Sekido Y. 2007. Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas. Hepatol. Res. 37:974–983 - PubMed
    1. Yuan Y, Wang Q, Paulk J, Kubicek S, Kemp MM, Adams DJ, Shamji AF, Wagner BK, Schreiber SL. 2012. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem. Biol. 7:1152–1157 - PMC - PubMed

Publication types

LinkOut - more resources