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. 2013 Aug 27;128(9):1021-30.
doi: 10.1161/CIRCULATIONAHA.113.001879.

Pathological ventricular remodeling: therapies: part 2 of 2

Min Xie  1 , Jana S Burchfield, Joseph A Hill
Affiliations

Pathological ventricular remodeling: therapies: part 2 of 2

Min Xie et al. Circulation. .
No abstract available

Keywords: apoptosis; autophagy; cell death; fibrosis; hypertrophy; inflammation; stem cells.

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Conflict of interest statement

Conflicts of Interest Disclosures: None.

Figures

Figure
Figure
Therapeutic interventions in pathological ventricular remodeling. Clinically proven pharmacological agents reduce morbidity and mortality, including ACE inhibitors, ARBs, β-blockers, and MRAs by reducing cell death, hypertrophy, and fibrosis. GLP-1 may prove effective in treating metabolic derangements. Mechanical support using ventricular assist device therapy unloads the failing myocardium and limits ventricular dilation. ICDs and CRTs target electrophysiological remodeling events. Finally, cell replacement therapy to replenish lost cardiomyocytes remains experimental and holds promise for the future.
See this image and copyright information in PMC

References

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    1. Burchfield JS, Xie M, Hill JA. Pathological ventricular remodeling: Mechanisms. Circulation. 2013;128:XX–XXX. - PMC - PubMed
    1. Liu Y, Haddad T, Dwivedi G. Heart failure with preserved ejection fraction: Current understanding and emerging concepts. Current opinion in cardiology. 2013;28:187–196. - PubMed

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