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. 2013 Nov;57(11):5743-6.
doi: 10.1128/AAC.00827-13. Epub 2013 Aug 26.

Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Masayuki Nigo  1 , Catalina Salinas Cevallos, Krystina Woods, Vicente Maco Flores, Gweneth Francis, David C Perlman, Manuel Revuelta, Donna Mildvan, Mary Waldron, Tessa Gomez, Sanjana Koshy, Tomasz Jodlowski, William Riley, Jörg J Ruhe
Affiliations

Nested case-control study of the emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae

Masayuki Nigo et al. Antimicrob Agents Chemother. 2013 Nov.

Abstract

We performed a nested case-control study (ratio of 1:4) on the emergence of tigecycline-resistant multidrug-resistant Klebsiella pneumoniae (TR-MDRKP) isolates among patients who initially presented with a tigecycline-susceptible MDRKP isolate. Out of 260 patients, 24 (9%) had a subsequent clinical culture positive for a TR-MDRKP isolate within the 90-day follow-up period. On logistic regression analyses, receipt of tigecycline (adjusted odds ratio [OR], 5.06; 95% confidence interval [CI], 1.80 to 14.23; P = 0.002) was the only independent predictor of subsequent isolation of a TR strain.

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