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. 2013 Sep 10;110(37):14829-32.
doi: 10.1073/pnas.1315180110. Epub 2013 Aug 26.

Brown and Goldstein: the cholesterol chronicles

Prashant Nair

Brown and Goldstein: the cholesterol chronicles

Prashant Nair. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
LDL in FH: A comparative look. Courtesy of Brown and Goldstein.
Fig. 2.
Fig. 2.
Partners for life: Brown and Goldstein circa 1975. Courtesy of Brown and Goldstein.
Fig. 3.
Fig. 3.
Electron micrographs of normal human skin cells (A) showing labeled LDL particles and the LDL receptor clustered in cell membrane pockets called coated pits. In Despota’s skin cells (B), however, most of the LDL receptor was found to be remote from the coated pits and randomly scattered across the membrane. Reprinted by permission of Macmillian Publishers, Ltd: Nature (3), copyright 1977.
See this image and copyright information in PMC

References

    1. Brown MS, Goldstein JL. Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. Proc Natl Acad Sci USA. 1974;71(3):788–792. - PMC - PubMed
    1. Brown MS, Goldstein JL. Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein. Cell. 1976;9(4 Pt 2):663–674. - PubMed
    1. Anderson RG, Goldstein JL, Brown MS. A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts. Nature. 1977;270(5639):695–699. - PubMed
    1. Brown MS, Goldstein JL. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997;89(3):331–340. - PubMed
    1. Ye J, et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell. 2000;6(6):1355–1364. - PubMed

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