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. 2013 May;57(3):265-9.
doi: 10.4103/0019-5049.115616.

Effect of supplementation of low dose intravenous dexmedetomidine on characteristics of spinal anaesthesia with hyperbaric bupivacaine

Ss Harsoor  1 , D Devika Rani, Bhavana Yalamuru, K Sudheesh, Ss Nethra
Affiliations

Effect of supplementation of low dose intravenous dexmedetomidine on characteristics of spinal anaesthesia with hyperbaric bupivacaine

Ss Harsoor et al. Indian J Anaesth. 2013 May.

Abstract

Aims: Intravenous (IV) dexmedetomidine with excellent sedative properties has been shown to reduce analgesic requirements during general anaesthesia. A study was conducted to assess the effects of IV dexmedetomidine on sensory, motor, haemodynamic parameters and sedation during subarachnoid block (SAB).

Methods: A total of 50 patients undergoing infraumbilical and lower limb surgeries under SAB were selected. Group D received IV dexmedetomidine 0.5 mcg/kg bolus over 10 min prior to SAB, followed by an infusion of 0.5 mcg/kg/h for the duration of the surgery. Group C received similar volume of normal saline infusion. Time for the onset of sensory and motor blockade, cephalad level of analgesia and duration of analgesia were noted. Sedation scores using Ramsay Sedation Score (RSS) and haemodynamic parameters were assessed.

Results: Demographic parameters, duration and type of surgery were comparable. Onset of sensory block was 66±44.14 s in Group D compared with 129.6±102.4 s in Group C. The time for two segment regression was 111.52±30.9 min in Group D and 53.6±18.22 min in Group C and duration of analgesia was 222.8±123.4 min in Group D and 138.36±21.62 min in Group C. The duration of motor blockade was prolonged in Group D compared with Group C. There was clinically and statistically significant decrease in heart rate and blood pressures in Group D. The mean intraoperative RSS was higher in Group D.

Conclusion: Administration of IV dexmedetomidine during SAB hastens the onset of sensory block and prolongs the duration of sensory and motor block with satisfactory arousable sedation.

Keywords: Dexmedetomidine; intravenous; subarachnoid block; supplementation.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Comparison of intra-operative haemodynamic parameters. Heart rate significantly low (P<0.05) in Group D from 30th min to 60th min. MAP significantly low (P<0.05) from 60thg min until the end of surgery
Figure 2
Figure 2
Post-operative haemodynamic parameters. MAP significantly low (P<0.05) in Group D for initial 2 h
See this image and copyright information in PMC

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