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Review
. 2013:2013:127170.
doi: 10.1155/2013/127170. Epub 2013 Jul 28.

Angiogenesis and its therapeutic opportunities

So Young Yoo  1 , Sang Mo Kwon
Affiliations
Review

Angiogenesis and its therapeutic opportunities

So Young Yoo et al. Mediators Inflamm. 2013.

Abstract

Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by "on-off switch signals" between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia) and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies). Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases.

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Figures

Figure 1
Figure 1
Processes in angiogenesis. (1) Angiogenic factors bind to their receptors on endothelial cells and activate the signal transduction pathways. (2) Matrix metalloproteinases are activated, and they degrade the extracellular matrix. (3) Endothelial cells migrate out of the preexisting capillary wall and proliferate. (4) Integrins are expressed by endothelial cells, facilitating their adhesion to the extracellular matrix and their migration for tube formation. (5) Angiopoietin 1 binds to Tie-2 receptors and stimulates pericyte recruitment and vessel stabilization.
See this image and copyright information in PMC

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