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. 2013 Aug 14:6:143-7.
doi: 10.2147/IJNRD.S46440. eCollection 2013.

Relationship between platelet count and hemodialysis membranes

Rabih Nasr  1 , Chadi Saifan, Iskandar Barakat, Yorg Al Azzi, Ali Naboush, Marc Saad, Suzanne El Sayegh
Affiliations

Relationship between platelet count and hemodialysis membranes

Rabih Nasr et al. Int J Nephrol Renovasc Dis. .

Abstract

Background: One factor associated with poor outcomes in hemodialysis patients is exposure to a foreign membrane. Older membranes are very bioincompatible and increase complement activation, cause leukocytosis by activating circulating factors, which sequesters leukocytes in the lungs, and activates platelets. Recently, newer membranes have been developed that were designed to be more biocompatible. We tested if the different "optiflux" hemodialysis membranes had different effects on platelet levels.

Methods: Ninety-nine maintenance hemodialysis patients with no known systemic or hematologic diseases affecting their platelets had blood drawn immediately prior to, 90 minutes into, and immediately following their first hemodialysis session of the week. All patients were dialyzed using a Fresenius Medical Care Optiflux polysulfone membrane F160, F180, or F200 (polysulfone synthetic dialyzer membranes, 1.6 m(2), 1.8 m(2), and 2.0 m(2) surface area, respectively, electron beam sterilized). Platelet counts were measured from each sample by analysis using a CBC analyzer.

Results: The average age of the patients was 62.7 years; 36 were female and 63 were male. The mean platelet count pre, mid, and post dialysis was 193 (standard deviation ±74.86), 191 (standard deviation ±74.67), and 197 (standard deviation ±79.34) thousand/mm3, respectively, with no statistical differences.

Conclusion: Newer membranes have no significant effect on platelet count. This suggests that they are, in fact, more biocompatible than their predecessors and may explain their association with increased survival.

Keywords: bioincompatible events; cellulosic membranes; complement activation; electron beam sterilized; platelet count; polysulfone membranes.

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Figures

Figure 1
Figure 1
Platelet count pre, mid, and post dialysis.
Figure 2
Figure 2
The platelet counts at the three different time points. Notes: The mean pre dialysis count was 193,000.86 per mm3, mid dialysis count was 191,000.27 per mm3, and the mean post dialysis platelet count was 197,000.16 per mm3.
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