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. 2013 Aug 14:5:287-94.
doi: 10.2147/CLEP.S46893. eCollection 2013.

Risk of miscarriage among users of corticosteroid hormones: a population-based nested case-control study

Anne-Mette B Bjørn  1 , Rikke B Nielsen, Mette Nørgaard, Ellen A Nohr, Vera Ehrenstein
Affiliations

Risk of miscarriage among users of corticosteroid hormones: a population-based nested case-control study

Anne-Mette B Bjørn et al. Clin Epidemiol. .

Abstract

Background: The purpose of this nested case-control study in Denmark was to study the association between use of corticosteroids and risk of miscarriage.

Methods: We identified prescriptions for corticosteroids before the miscarriage/index date. We estimated odds ratios (ORs) for miscarriage and for early (<13 weeks) and late (13-21 weeks) miscarriage adjusting for age, history of diabetes and epilepsy, and nonsteroidal anti-inflammatory drug use.

Results: We identified 10,974 women with miscarriage and 109,740 controls. Prevalence of inhaled corticosteroid use within 60 days before the index date was 1.3% among the cases and 1.0% among the controls (OR = 1.20; 95% confidence interval [CI] 1.01-1.44). Prevalence of oral corticosteroid use within 60 days before the index date was 0.3% for both cases and controls (OR = 0.78; 95% CI 0.53-1.15). For inhaled and oral corticosteroids, the ORs of early miscarriage were 1.22 (95% CI 1.01-1.49) and 0.81 (95% CI 0.55-1.20), respectively.

Conclusion: Use of inhaled corticosteroids was associated with a slightly increased risk of early miscarriage, but explanations alternative to causal ones were possible.

Keywords: case-control study; corticosteroid hormones; epidemiology; miscarriage.

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References

    1. Chrousos G. Adrenocorticosteroids and adrenocortical antagonists. In: Katzung B, editor. Basic and Clinical Pharmacology. 10th edition. New York, NY: McGraw-Hill Companies Inc; 2007.
    1. Kwon HL, Belanger K, Bracken MB. Asthma prevalence among pregnant and childbearing-aged women in the United States: estimates from National Health Surveys. Ann Epidemiol. 2003;13:317–324. - PubMed
    1. Loftus EV., Jr Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504–1517. - PubMed
    1. Carmichael SL, Shaw GM, Ma C, et al. Maternal corticosteroid use and orofacial clefts. Am J Obstet Gynecol. 2007;197:585. e1–e7. - PubMed
    1. McGee DC. Steroid use during pregnancy. J Perinat Neonatal Nurs. 2002;16:26–39. - PubMed

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