Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:153180.
doi: 10.1155/2013/153180. Epub 2013 Jul 24.

Unexpected diagnosis of both adenocarcinoma of the colon and metastatic lobular carcinoma of the breast in the gastrointestinal tract

Tegan Miller  1 , Carol Ross, Haitham Al-Rawi, Barry Taylor, Mohammad Al-Jafari
Affiliations

Unexpected diagnosis of both adenocarcinoma of the colon and metastatic lobular carcinoma of the breast in the gastrointestinal tract

Tegan Miller et al. Case Rep Pathol. 2013.

Abstract

Breast cancer rarely metastasises to the gastrointestinal tract. Lobular carcinoma more commonly metastasises to the uterus and appendages, peritoneum, and gastrointestinal tract than other types of breast cancer, while ductal carcinoma has a propensity to metastasise to the lungs, liver, and brain. We describe the case of a patient with no known history of breast cancer, whose primary presentation of lobular breast cancer was with malignant small intestinal and colonic strictures, with coexisting previously undiagnosed adenocarcinoma of the colon.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Low power light microscopy image demonstrating well-differentiated adenocarcinoma (upper right of image) and small noncohesive cells with the appearance of metastatic infiltration (lower left of image).
Figure 2
Figure 2
High power light microscopy image of metastatic cells showing the classical appearance of lobular carcinoma of the breast with discohesive cells forming an “Indian file.”
Figure 3
Figure 3
Immunohistochemical staining with CK 7 demonstrating negative adenocarcinoma uptake and positive metastatic carcinoma uptake.
See this image and copyright information in PMC

References

    1. Aurello P, D’Angelo F, Cosenza G, et al. Gastric metastasis 14 years after mastectomy for breast lobular carcinoma: case report and literature review. American Surgeon. 2006;72(5):456–460. - PubMed
    1. Ambroggi M, Stroppa EM, Mordenti P, et al. Metastatic breast cancer to the gastrointestinal tract: report of five cases and review of the literature. International Journal of Breast Cancer. 2012;2012:8 pages.439023 - PMC - PubMed
    1. Yeh IT, Mies C. Application of immunohistochemistry to breast lesions. Archives of Pathology and Laboratory Medicine. 2008;132(3):349–358. - PubMed
    1. Ciulla A, Castronovo G, Tomasello G, et al. Gastric metastases originating from occult breast lobular carcinoma: diagnostic and therapeutic problems. World Journal of Surgical Oncology. 2008;6(article 78) - PMC - PubMed
    1. Puglisi M, Varaldo E, Assalino M, Ansaldo G, Torre G, Borgonovo G. Anal metastasis from recurrent breast lobular carcinoma: a case report. World Journal of Gastroenterology. 2009;15(11):1388–1390. - PMC - PubMed

LinkOut - more resources