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Comment
. 2013 Sep;45(9):964-5.
doi: 10.1038/ng.2736.

APOBEC3B mutagenesis in cancer

Kawai J Kuong, Lawrence A Loeb
Comment

APOBEC3B mutagenesis in cancer

Kawai J Kuong et al. Nat Genet. 2013 Sep.

Abstract

Recent evidence has implicated APOBEC3B as a source of mutations in cervical, bladder, lung, head and neck, and breast cancers. APOBEC enzymes normally function in innate immune responses, including those that target retroviruses, suggesting links between mutagenesis, immunity and viral infection in the process of cancer development.

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Figures

Figure 1
Figure 1
Mutation signatures and cancer. There are many sources of mutagenic activity that contribute to tumorigenesis. APOBEC3B, which has a known role in innate immune responses, is now implicated as a source of mutation in cervical, bladder, lung, head and neck, and breast cancers. ROS, reactive oxygen species.
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