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. 2013 Aug 27;11(9):3288-96.
doi: 10.3390/md11093288.

Secosteroids and norcembranoids from the soft coral Sinularia nanolobata

Yen-Ju Tseng  1 , Shang-Kwei Wang, Chang-Yih Duh
Affiliations

Secosteroids and norcembranoids from the soft coral Sinularia nanolobata

Yen-Ju Tseng et al. Mar Drugs. .

Abstract

Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9, 11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9, 11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis. The anti-HCMV (human cytomegalovirus) activity of 1-4 and its cytotoxicity against selected cell lines were evaluated.

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Figures

Figure 1
Figure 1
Structures of Metabolites 1–6.
Figure 2
Figure 2
Selected 1H−1H COSY (▬) and HMBC (→) correlations of 1 and 2.
Figure 3
Figure 3
Key NOESY Correlations for 1 and 2.
See this image and copyright information in PMC

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