Slide to the left and slide to the right: motor coordination in neurons
- PMID: 23987508
- DOI: 10.1016/j.devcel.2013.08.009
Slide to the left and slide to the right: motor coordination in neurons
Abstract
Molecular motors employ specific adaptor proteins to dock on transport cargos. Reporting in The Journal of Cell Biology, Fu and Holzbaur (2013) show that the adaptor JNK interacting protein 1 (JIP1) binds kinesin-1 and dynactin and controls bidirectional axonal amyloid precursor protein trafficking, suggesting a regulatory role for adaptors during cargo transport.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.J Cell Biol. 2013 Aug 5;202(3):495-508. doi: 10.1083/jcb.201302078. Epub 2013 Jul 29. J Cell Biol. 2013. PMID: 23897889 Free PMC article.
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