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. 2013 Aug 29;5(1):47.
doi: 10.1186/1758-5996-5-47.

Direct cardiovascular effects of glucagon like peptide-1

Asfandyar Sheikh  1
Affiliations

Direct cardiovascular effects of glucagon like peptide-1

Asfandyar Sheikh. Diabetol Metab Syndr. .

Abstract

Current gold standard therapeutic strategies for T2DM target insulin resistance or β cell dysfunction as their core mechanisms of action. However, the use of traditional anti-diabetic drugs, in most cases, does not significantly reduce macrovascular morbidity and mortality. Among emerging anti-diabetic candidates, glucagon like peptide-1 (GLP-1) based therapies carry special cardiovascular implications, exerting both direct as well as indirect effects. The direct cardiovascular effects of GLP-1 and its analogs remain the focus of this review.

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Figures

Figure 1
Figure 1
Cardiometabolic actions of GLP-1 and GLP-1 agonists [7].
Figure 2
Figure 2
Mechanism of action of GLP-1 [25].
Figure 3
Figure 3
Cardiovascular effects of DPP-4 inhibitors [27].
See this image and copyright information in PMC

References

    1. WHO | Cardiovascular diseases (CVDs) http://www.who.int/mediacentre/factsheets/fs317/en/index.html.
    1. Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, Finkelstein EA, Hong Y, Johnston SC, Khera A. Forecasting the future of cardiovascular disease in the United States a policy statement from the American heart association. Circulation. 2011;123(8):933–944. doi: 10.1161/CIR.0b013e31820a55f5. - DOI - PubMed
    1. Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, Sowers JR. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. 1999;100(10):1134–1146. doi: 10.1161/01.CIR.100.10.1134. - DOI - PubMed
    1. Lind M, Garcia-Rodriguez LA, Booth GL, Cea-Soriano L, Shah BR, Ekeroth G, Lipscombe LL. Mortality trends in patients with and without diabetes in Ontario, Canada and the UK from 1996 to 2009: a population-based study. Diabetologia. 2013. in press. - PubMed
    1. Action to Control Cardiovascular Risk in Diabetes (ACCORD) http://clinicaltrials.gov/ct2/show/NCT00000620.