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. 2013 Nov;27(8):1105-14.
doi: 10.1016/j.avsg.2013.01.010. Epub 2013 Aug 26.

Systematic review on health-related quality of life after revascularization and primary amputation in patients with critical limb ischemia

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Systematic review on health-related quality of life after revascularization and primary amputation in patients with critical limb ischemia

Jan Bosma et al. Ann Vasc Surg. 2013 Nov.

Abstract

Background: The purpose of this study was to assess the effect of revascularization (bypass surgery, angioplasty) and primary amputation on health-related quality of life (QoL) in patients with critical limb ischemia (CLI; resting pain or tissue loss).

Methods: A systematic review of the literature was performed through an electronic search of PubMed (from 1985 to 2012) and Embase (from 1985 to 2012) by two independent investigators to identify English-language articles investigating health-related QoL in regard to CLI.

Results: Three observational studies were identified describing a comparison between primary amputation and revascularization and their effects on QoL in patients with CLI, all concluding that revascularization should be attempted. Data pooling was omitted due to the impossibility of combining outcome parameters. A separate analysis of each article is presented.

Conclusions: Patients with CLI have poor health prospects and life expectancy, irrespective of treatment administered. Randomized trials of health-related QoL after revascularization versus primary amputation are nonexistent. Also, the available observational studies do not allow sound conclusions, due to small numbers and methodologic imperfections. Therefore, no recommendations of either therapy in patients with CLI can be made with respect to an anticipated improvement in QoL.

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