Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis

Abstract

Objectives: To define the prognostic value of different histological subtypes of colorectal cancer.

Background: Most colorectal cancers are classical adenocarcinomas (AC). Less frequent subtypes include mucinous adenocarcinomas (MAC) and signet-ring cell carcinomas (SC). In contrast to established prognostic factors such as TNM and grading, the histological subtype has no therapeutical consequences so far, although it may reflect different biological behavior.

Methods: Between 1982 and 2012, a total of 3479 consecutive patients underwent surgery for primary colorectal cancer (AC, MAC, or SC). Clinical, histopathological, and survival data were analyzed.

Results: Of all 3479 patients, histological subtype was AC in 3074 cases (88%), MAC in 375 cases (11%), and SC in 30 cases (0.9%). MAC (51%, P < 0.001) and SC (50%, P = 0.029) occurred more frequently in right-sided tumors than AC (28%). Compared with AC, tumor stages and histological grading were higher in MAC and SC (P < 0.001 for each). Rates of angioinvasion were lower in MAC than in AC (5% vs 9%, P = 0.011). Rates of lymphatic invasion were higher in SC than in AC (67% vs 25%, P < 0.001). Five-year cause-specific survival was 67 ± 1% for AC, 61 ± 3% for MAC, and 21 ± 8% for SC (P < 0.001 for difference between the groups). In multivariable analysis, survival did not differ significantly between AC and MAC after correction for tumor stage. However, SC remained an independent prognostic factor associated with worse survival (hazard ratio = 2.5, 95% confidence interval = 1.6-3.8, P < 0.001).

Conclusions: MAC and SC are histological subtypes of colorectal cancer with different characteristics than classical AC. Both are diagnosed in more advanced tumor stages, but the dismal prognosis of SC seems to be caused by its intrinsic tumor biology.

FIGURE 1.

Cause-specific survival for patients of all stages, corresponding to adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma.

FIGURE 2.

Cause-specific survival for patients with (A) adenocarcinoma, (B) mucinous adenocarcinoma, and (C) signet-ring cell carcinoma, corresponding to colon cancer and rectal cancer.

FIGURE 3.

Cause-specific survival for patients of (A) stage I, (B) stage II, (C) stage III, and (D) stage IV, corresponding to adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma. Levels of significance are listed in Table 4.