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Comment
. 2013 Sep;84(3):427-9.
doi: 10.1038/ki.2013.140.

Tissue protection by erythropoietin: new findings in a moving field

Masaomi Nangaku  1
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Free article
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Tissue protection by erythropoietin: new findings in a moving field

Masaomi Nangaku. Kidney Int. 2013 Sep.
Free article

Abstract

Two groups elucidate novel mechanisms of tissue protection by erythropoietin (EPO). Hu et al. demonstrate that Klotho's protective effect against oxidant-induced cytotoxicity is partially mediated by an increase in the endogenous expression of the classical EPO receptor (EpoR). While erythropoiesis is stimulated by the canonical EpoR homodimer, the tissue-protective effects of EPO are mediated through a heterodimeric 'tissue-protective' receptor. Coldewey et al. demonstrate a protective role of the 'tissue-protective' EpoR against acute kidney injury.

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