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Review
. 2013 Aug 28;14(9):17573-83.
doi: 10.3390/ijms140917573.

Prevention of carcinogenesis and development of gastric and colon cancers by 2-aminophenoxazine-3-one (Phx-3): direct and indirect anti-cancer activity of Phx-3

Akio Tomoda  1 , Keisuke Miyazawa, Takafumi Tabuchi
Affiliations
Review

Prevention of carcinogenesis and development of gastric and colon cancers by 2-aminophenoxazine-3-one (Phx-3): direct and indirect anti-cancer activity of Phx-3

Akio Tomoda et al. Int J Mol Sci. .

Abstract

2-Aminophenoxazine-3-one (Phx-3), an oxidative phenoxazine, exerts strong anticancer effects on various cancer cell lines originating from different organs, in vitro. This article reviews new aspects for the prevention of carcinogenesis and development of gastric and colon cancers by Phx-3, based on the strong anticancer effects of Phx-3 on gastric and colon cancer cell lines (direct anticancer effects of Phx-3 for preventing development of cancer), the bacteriocidal effects of Phx-3 against Helicobacter pylori associated with carcinogenesis of gastric cancer (indirect anticancer effects for preventing carcinogenesis of gastric cancer), and the proapoptotic activity of Phx-3 against human neutrophils involved in the incidence of ulcerative colitis associated with a high colon cancer risk (indirect anticancer effects for preventing carcinogenesis of colon cancer).

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Figures

Figure 1
Figure 1
Chemical structure of Phx-3.
Scheme 1
Scheme 1
Plausible mechanism for anticancer effects of Phx-3 on gastric and colon cancer cells.
See this image and copyright information in PMC

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