Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Aug 28;5(9):2062-78.
doi: 10.3390/v5092062.

Recombinant Salmonella enterica serovar Typhimurium as a vaccine vector for HIV-1 Gag

Nyasha Chin'ombe  1
Affiliations
Review

Recombinant Salmonella enterica serovar Typhimurium as a vaccine vector for HIV-1 Gag

Nyasha Chin'ombe. Viruses. .

Abstract

The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune responses. Oral, attenuated recombinant Salmonella vaccines offer this potential of delivering HIV-1 antigens to both the mucosal and systemic compartments of the immune system. So far, a number of pre-clinical studies have been performed, in which HIV-1 Gag, a highly conserved viral antigen possessing both T- and B-cell epitopes, was successfully delivered by recombinant Salmonella vaccines and, in most cases, induced HIV-specific immune responses. In this review, the potential use of Salmonella enterica serovar Typhimurium as a live vaccine vector for HIV-1 Gag is explored.

PubMed Disclaimer

References

    1. Brenner D.J. Enterobacteriaceae. In: Krieg N.B., Holt J.G., editors. Bergey’s Manual of Systemic Bacteriology. Volume 1 Williams and Wilkins; Baltimore, MD, USA: 1984.
    1. Farmer J.J. Enterobacteriaceae: Introduction and identification. In: Murray P.R., Baron E.J., Jorgensen J.H., Pfaller M.A., Yolken R.H., editors. Manual of Clinical Microbiology. ASM Press; Washington, DC, USA: 2003.
    1. Ohl M.E., Miller S.I. Salmonella: A model for bacterial pathogenesis. Annu. Rev. Med. 2001;52:259–274. - PubMed
    1. Miller S.I., Pegues D.A. Salmonella species, including Salmonella Typhi. In: Mandell G.L., Bennett J.E., Dolin R., editors. Principles and Practice of Infectious Diseases. Churchill Livingstone; Philadelphia, PA, USA: 2000.
    1. Uzzau S., Brown D.J., Wallis T., Rubino S., Leori G., Bernard S., Casadesus J., Platt D.J., Olsen J.E. Host adapted serotypes of Salmonella enterica. Epidemiol. Infect. 2000;125:229–255. doi: 10.1017/S0950268899004379. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources