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. 2013 Dec 15;208(12):1962-7.
doi: 10.1093/infdis/jit440. Epub 2013 Aug 29.

Cytokine and chemokine levels in patients infected with the novel avian influenza A (H7N9) virus in China

Ying Chi  1 , Yefei Zhu, Tian Wen, Lunbiao Cui, Yiyue Ge, Yongjun Jiao, Tao Wu, Aihua Ge, Hong Ji, Ke Xu, Changjun Bao, Zheng Zhu, Xian Qi, Bin Wu, Zhiyang Shi, Fenyang Tang, Zheng Xing, Minghao Zhou
Affiliations

Cytokine and chemokine levels in patients infected with the novel avian influenza A (H7N9) virus in China

Ying Chi et al. J Infect Dis. .

Abstract

H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Th17 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.

Keywords: H7N9 avian influenza; chemokine; cytokine.

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