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. 2013 Aug 18;6(4):448-51.
doi: 10.3980/j.issn.2222-3959.2013.04.07. eCollection 2013.

Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma

Qing-Shan Ji  1 , Bing Qi, Lian Liu, Wei Lao, Zhi-Hao Yang, Gui-Fang Wang, Guo-Cheng Yu, Jing-Xiang Zhong
Affiliations

Comparison of trabeculectomy and trabeculectomy with amniotic membrane transplantation in the same patient with bilateral glaucoma

Qing-Shan Ji et al. Int J Ophthalmol. .

Abstract

Aim: To observe effects of trabeculectomy with amniotic membrane transplantation (AMT) in controlling postoperative intraocular pressure (IOP) in patients with medically uncontrolled glaucoma.

Methods: This study included adult patients with requiring bilateral glaucoma surgery. Each patient underwent trabeculectomy (Non-AMT group) in one eye and with AMT (AMT group) in the other eye according to randomized principle. Success was defined as intraocular pressure (IOP)<21mmHg without any anti-glaucoma medications at 24 months follow-up. The two groups were compared in terms of IOP, complications and success rate.

Results: Thirty-four eyes of 17 patients were investigated in this study. There was no statistically signifcant difference in pre-operative IOP between the two groups. The mean IOP was lower in AMT group compared with Non-AMT group on follow up months 12, 18, and 24.Postoperative complications were more frequent in Non-AMT group (35.3%, 6/17) compared with AMT group (5.9%, 1/17). The success rate of surgery was 88.2% (15/17) in Non-AMT group and 100% (17/17) in AMT group.

Conclusion: Trabeculectomy with AMT is an effective procedure to reduce IOP and complications, thereby improving surgical success rates.

Keywords: amniotic membrane transplantation; glaucoma; trabeculectomy.

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Figures

Figure 1
Figure 1. Pre- and post-operative IOP.
Figure 2
Figure 2. Time trend of the average difference in IOP between AMT and Non-AMT groups from 1 month after surgery to 24 months.
See this image and copyright information in PMC

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