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. 2013 Nov-Dec;37(6):1094-7.
doi: 10.1016/j.clinimag.2013.04.004. Epub 2013 Aug 29.

18F-FDG PET/CT superior to serum CEA in detection of colorectal cancer and its recurrence

William Makis  1 , David Kurzencwyg, Marc Hickeson
Affiliations

18F-FDG PET/CT superior to serum CEA in detection of colorectal cancer and its recurrence

William Makis et al. Clin Imaging. 2013 Nov-Dec.

Abstract

The aim of this study was to examine whether positron emission tomography (PET)/computed tomography (CT) can detect more cases of colorectal cancer (CRC) than serum carcinoembryonic antigen (CEA), both at initial staging and during surveillance for recurrence. A retrospective review of 639 CRC patients imaged with PET/CT was performed. PET/CT was superior to serum CEA in detecting CRC, identifying 2.5 times as many CRC at initial staging compared to serum CEA and 1.5 times as many CRC recurrences. The current guideline recommendations of utilizing PET/CT only in the context of a rising serum CEA will miss more than one third of all CRC recurrences.

Keywords: CEA; Carcinoembryonic antigen; Colorectal cancer; FDG; PET/CT.

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