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. 2013 Nov 15;29(22):2931-2.
doi: 10.1093/bioinformatics/btt501. Epub 2013 Aug 30.

TALENoffer: genome-wide TALEN off-target prediction

Jan Grau  1 , Jens Boch, Stefan Posch
Affiliations

TALENoffer: genome-wide TALEN off-target prediction

Jan Grau et al. Bioinformatics. .

Abstract

Summary: Transcription activator-like effector nucleases (TALENs) have become an accepted tool for targeted mutagenesis, but undesired off-targets remain an important issue. We present TALENoffer, a novel tool for the genome-wide prediction of TALEN off-targets. We show that TALENoffer successfully predicts known off-targets of engineered TALENs and yields a competitive runtime, scanning complete mammalian genomes within a few minutes.

Availability: TALENoffer is available as a command line program from http://www.jstacs.de/index.php/TALENoffer and as a Galaxy server at http://galaxy.informatik.uni-halle.de.

Contact: grau@informatik.uni-halle.de

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