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. 2012 Mar;3(1):56-64.
doi: 10.1007/s12975-011-0133-.

MRI of blood-brain barrier permeability in cerebral ischemia

Quan Jiang  1 , James R Ewing, Michael Chopp
Affiliations

MRI of blood-brain barrier permeability in cerebral ischemia

Quan Jiang et al. Transl Stroke Res. 2012 Mar.

Abstract

Quantitative measurement of blood-brain barrier (BBB) permeability using MRI and its application to cerebral ischemia are reviewed. Measurement of BBB permeability using MRI has been employed to evaluate ischemic damage during acute and subacute phases of stroke and to predict hemorrhagic transformation. There is also an emerging interest on the development and use of MRI to monitor vascular structural changes and angiogenesis during stroke recovery. In this review, we describe MRI BBB permeability and susceptibility-weighted MRI measurements and its applications to evaluate ischemic damage during the acute and subacute phases of stroke and vascular remodeling during stroke recovery.

Keywords: Angiogenesis; Blood-to-brain transfer constant; Blood–brain barrier permeability; Dynamic contrast-enhanced MRI; Hemorrhage; Ischemia; MRI; Vascular remodeling.

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Figures

Fig. 1
Fig. 1
Vascular parameters of tracer transport and exchange in the damaged tissue. Flow plasma flow, Fp; shunt flow where there is no exchange of waste or nutrients with the tissue, perfusion nutritive flow, PS permeability-surface area product, E extracted fraction, VD* volume of distribution—not all of the tissue volume is “available” to the extracted tracer (in the case of Gd-DTPA, this represents the interstitial volume, Ve). Modified from ref. [133]
Fig. 2
Fig. 2
Angiogenesis appearances in MRI Ktrans and SWI after stroke with and without treatment: Ktrans maps (a, b) and SWI (c, d) images exhibited early increases in Ktrans (b, red arrow) and the dark lines in SWI (d, white arrowhead) in the angiogenesis related areas for the treated compared to the control rat (a, c)
See this image and copyright information in PMC

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