Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul;7(7):1303-6.
doi: 10.7860/JCDR/2013/5269.3123. Epub 2013 Jul 1.

A study of serum apolipoprotein A1, apolipoprotein B and lipid profile in stroke

Shilpasree As  1 , Savitri Sahukar, Jayaprakash Murthy, Kiran Kumar
Affiliations

A study of serum apolipoprotein A1, apolipoprotein B and lipid profile in stroke

Shilpasree As et al. J Clin Diagn Res. 2013 Jul.

Abstract

Background: Role of Serum Lipids, Lipoproteins and Lipoprotein related variables in the prediction of Stroke is less clear. Abnormalities in plasma Lipoproteins are the most firmly established and best understood risk factors for Atherosclerosis and they are probable risk factors for Ischaemic stroke, largely by their link to Atherosclerosis. Apo B reflects the concentration of potentially atherogenic particles (LDL), and Apo A1 reflects the corresponding concentration of anti- atherogenic particles (HDL), represent additional lipoprotein related variables that may indicate the vascular risk.

Aim: To study serum concentration of Apolipoprotein A1, Apolipoprotein B, Apo B/Apo A1 ratio and Lipid profile in Stroke Cases and to compare with healthy controls.

Design: A total number of 100 subjects within 30 - 70 years were considered for the study. 50 subjects with Stroke (both clinically as well as Computed tomographically proven cases) and 50 age and sex matched healthy individuals were taken for the study.

Material and methods: Total cholesterol, HDL cholesterol and Triglycerides are estimated by Enzymatic method using Semiautoanalyser. LDL cholesterol is estimated by Friedewald formula. Apo B and Apo A1 are estimated by Immunoturbidimetric method using Semiautoanalyser.

Statistical analysis: Student 't' test was used to compare the data between cases and controls. Diagnostic validity tests were conducted to assess the Diagnostic efficiency of Apo A1, Apo B and Apo B/Apo A1 ratio.

Results: Total cholesterol, LDL cholesterol and Triglycerides are significantly increased in Cases compared to Controls. HDL - cholesterol is significantly decreased in Cases compared to Controls. Apo B and Apo B/Apo A1 ratio are significantly increased and Apo A1 is significantly decreased in Cases compared to Controls. Diagnostic validity tests showed that, Apo B , Apo A1 and Apo B /Apo A1 ratio have highest Sensitivity, Specificity and Diagnostic efficiency.

Conclusion: Apo B , Apo A1 and Apo B / Apo A1 ratio can be used as predictors of stroke along with traditional lipid profile components.

Keywords: Apolipoprotein A1; Apolipoprotein B; Lipid profile; Stroke.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Smith W, Hauser SL, Easton D J. Harrisons Principles of Internal Medicine. 15th edn. Vol.2. USA: Mc Graw Hill Co; 2001. Cerebrovascular diseases. In : Brunwald E, Hauser SL, Fauci AS, Longo DL, Kasper DL, Jameson J L. eds; pp. 2369–85.
    1. Non communicable diseases in Park, Park (eds) Parks textbook of preventive and social medicine. 19th edn. Jabalpur: Banarasidas Bhanot; 2005. pp. 314–15.
    1. Mackay-Lyons M, Gubitz G, Giacomatonio N, Wightman H, Masters D, et al. Program of rehabilitative exercise and education to avert vascular events after nondisabling stroke or transient ischemic attack (PRVENT TRIAL): A multicentered, rhandomised controlled trial. BMC Neurology. 2010;10:122. - PMC - PubMed
    1. Koren-Morag N, Goldbourt U, Graff E, Tanne D. Apolipoproteins B and A1 and the risk of ischemic cerebrovascular events in patients with preexisting atherothrombotic disease. J Neurol Sci. 2008;270:82–87. - PubMed
    1. Imamura T, Doiy, Arima H, Yonemoto K, Hata J, Kubo M, et al. LDL cholesterol and the development of stroke subtypes and coronary heart disease in general Japanese population: The Hisayama study. Stroke. 2009;40:382–88. - PubMed