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Review
. 2013 Aug 21;15(4):218.
doi: 10.1186/ar4256.

Update on differences between childhood-onset and adult-onset systemic lupus erythematosus

Rina Mina, Hermine I Brunner
Review

Update on differences between childhood-onset and adult-onset systemic lupus erythematosus

Rina Mina et al. Arthritis Res Ther. .

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease and occurs worldwide in both children and adults. The estimated annual incidence among children is 2.22/100,000 and among adults is 23.2/100,000 in the United States. There is increasing understanding about differences in disease manifestations, medication use, and disease severity between those with childhood-onset SLE as compared with adult-onset SLE. Children have a more fulminant disease onset and course than adults with SLE, resulting in two to three times higher mortality. In future years, we anticipate more insight into the genetics between childhood-onset SLE and adult-onset SLE to help delineate the best therapies for both subsets of patients.

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