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. 2013 Oct 18;52(43):11303-7.
doi: 10.1002/anie.201305010. Epub 2013 Sep 2.

Chemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen

Lin Zhang  1 , Xihe Bi, Xiaoxue Guan, Xingqi Li, Qun Liu, Badru-Deen Barry, Peiqiu Liao
Affiliations

Chemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen

Lin Zhang et al. Angew Chem Int Ed Engl. .

Abstract

Aldehyde Termination: A novel copper-catalyzed transformation from methyl ketones into aldehydes has been accomplished. This method is applicable to a wide range of aromatic and aliphatic methyl ketones and chemoselectively produces aldehydes, accompanied by the release of hydrogen (H2 ) and carbon dioxide (CO2 ) as by-products.

Keywords: aldehydes; cleavage reactions; copper; ketones; oxygen.

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