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Review
. 2013 Dec;29(1-4):123-9.
doi: 10.1016/j.trim.2013.08.005. Epub 2013 Aug 31.

Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers

Liang Wei  1 , Xue Gong, Olivia M Martinez, Sheri M Krams
Affiliations
Review

Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers

Liang Wei et al. Transpl Immunol. 2013 Dec.

Abstract

MicroRNAs (miRNAs) are important regulators in many biologic processes and have been implicated in the control of genes relevant to acute rejection and liver functions. Here we review the miRNAs specifically expressed in allografts during acute rejection and discuss potential roles for these miRNAs in liver dysfunction. We focus on miRNAs dysregulated both in the liver and in peripheral blood mononuclear cells and include a discussion of the potential for these miRNAs as non-invasive biomarkers to reflect liver status posttransplant.

Keywords: Acute rejection; Circulating miRNA; Liver dysfunction; Liver transplantation; MicroRNA; Noninvasive biomarker.

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Figures

Figure 1
Figure 1. Differential expression of miRNAs associates with liver allograft rejection
Each column corresponds to the expression profile of syngeneic or allogeneic liver grafts on day 7 posttransplant. The color of each cell reflects the fold-change of the expression level of each miRNA relative to the average expression level across all samples. Green represents a decrease in expression, whereas red represents an increase. A. Unsupervised hierarchical clustering of overall miRNAs expression in liver grafts. B. Unsupervised hierarchical clustering of the miRNAs with differential expression at p < 0.05 in liver grafts.
See this image and copyright information in PMC

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