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. 2013 Sep;88(9):952-62.
doi: 10.1016/j.mayocp.2013.06.006.

The Mayo Clinic Biobank: a building block for individualized medicine

Janet E Olson  1 , Euijung Ryu, Kiley J Johnson, Barbara A Koenig, Karen J Maschke, Jody A Morrisette, Mark Liebow, Paul Y Takahashi, Zachary S Fredericksen, Ruchi G Sharma, Kari S Anderson, Matthew A Hathcock, Jason A Carnahan, Jyotishman Pathak, Noralane M Lindor, Timothy J Beebe, Stephen N Thibodeau, James R Cerhan
Affiliations

The Mayo Clinic Biobank: a building block for individualized medicine

Janet E Olson et al. Mayo Clin Proc. 2013 Sep.

Erratum in

  • Mayo Clin Proc. 2014 Feb;89(2):276

Abstract

Objective: To report the design and implementation of the first 3 years of enrollment of the Mayo Clinic Biobank.

Patients and methods: Preparations for this biobank began with a 4-day Deliberative Community Engagement with local residents to obtain community input into the design and governance of the biobank. Recruitment, which began in April 2009, is ongoing, with a target goal of 50,000. Any Mayo Clinic patient who is 18 years or older, able to consent, and a US resident is eligible to participate. Each participant completes a health history questionnaire, provides a blood sample, and allows access to existing tissue specimens and all data from their Mayo Clinic electronic medical record. A community advisory board provides ongoing advice and guidance on complex decisions.

Results: After 3 years of recruitment, 21,736 individuals have enrolled. Fifty-eight percent (12,498) of participants are female and 95% (20,541) of European ancestry. Median participant age is 62 years. Seventy-four percent (16,171) live in Minnesota, with 42% (9157) from Olmsted County, where the Mayo Clinic in Rochester, Minnesota, is located. The 5 most commonly self-reported conditions are hyperlipidemia (8979, 41%), hypertension (8174, 38%), osteoarthritis (6448, 30%), any cancer (6224, 29%), and gastroesophageal reflux disease (5669, 26%). Among patients with self-reported cancer, the 5 most common types are nonmelanoma skin cancer (2950, 14%), prostate cancer (1107, 12% in men), breast cancer (941, 4%), melanoma (692, 3%), and cervical cancer (240, 2% in women). Fifty-six percent (12,115) of participants have at least 15 years of electronic medical record history. To date, more than 60 projects and more than 69,000 samples have been approved for use.

Conclusion: The Mayo Clinic Biobank has quickly been established as a valuable resource for researchers.

Keywords: BMI; BRFSS; Behavioral Risk Factor Surveillance System Survey; CAB; Community Advisory Board; DCE; Deliberative Community Engagement; EMR; WBC; body mass index; electronic medical record; white blood cell.

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Conflict of interest statement

Conflicts of interest: None

Figures

Figure 1
Figure 1
Depth of the electronic medical records (EMR) for Mayo Clinic Biobank participants, using the length (panel A) of the EMR and the average number of visits per year (panel B). The maximum length of EMR available in Mayo Clinic is 19 years.
Figure 1
Figure 1
Depth of the electronic medical records (EMR) for Mayo Clinic Biobank participants, using the length (panel A) of the EMR and the average number of visits per year (panel B). The maximum length of EMR available in Mayo Clinic is 19 years.
See this image and copyright information in PMC

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