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. 2013 Summer;40(2):59-64.

Descriptive epidemiology of malignant primary osteosarcoma using population-based registries, United States, 1999-2008

Linh M Duong, Lisa C Richardson

Descriptive epidemiology of malignant primary osteosarcoma using population-based registries, United States, 1999-2008

Linh M Duong et al. J Registry Manag. 2013 Summer.

Abstract

Background: Osteosarcoma is a rare bone tumor that is the most frequently diagnosed among children and adolescents, although this cancer affects people of all ages. This study aims to augment the current literature by examining the incidence of osteosarcoma by its subsites on a national level.

Methods: Data from central cancer registries in the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology, and End Results (SEER) programs for diagnosis years 1999-2008 and covering 90.1 percent of the US population were analyzed. Analyses included cases of malignant primary osteosarcomas, which were further segmented by topography, appendicular (C40) and axial (C41), to assess differences between these sites. Descriptive statistics, including estimated age-adjusted incidence rates standardized to the 2000 US standard population, were calculated using SEER*Stat 7.0.5 software.

Results: Approximately 7,104 cases of malignant primary osteosarcomas were identified during 1999-2008, of which 5,379 were appendicular and 1,725 were axial. The incidence of malignant primary osteosarcomas differed by age, gender, race, ethnicity, region, grade, and stage. These differences in incidence persisted when malignant primary osteosarcomas were categorized by topography codes.

Conclusions: These analyses provide a better understanding of the incidence of malignant osteosarcoma which cover 90.1 percent of the US population from 1999-2008. This study provides a more detailed understanding of age, gender, race, and ethnicity by primary site for malignant osteosarcoma incidence on a national level in the United States. More importantly, differences between appendicular and axial sites were observed overall by selected demographic characteristics, in particular regional variations.

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Figures

Figure 1
Figure 1. Incidence of Primary Malignant Osteosarcomas, United States, 1999-2008
Rates are per million persons and age-adjusted to the 2000 US standard population (19 age groups—Census P25-1130). Rates pertain to 90.1% of the US population covered by eligible cancer registries. Data from 7 central cancer registries are not included.
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