Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug;25(3):368-70.
doi: 10.5021/ad.2013.25.3.368. Epub 2013 Aug 13.

Severe refractory atopic dermatitis in an adolescent patient successfully treated with ustekinumab

Affiliations

Severe refractory atopic dermatitis in an adolescent patient successfully treated with ustekinumab

Anna Agusti-Mejias et al. Ann Dermatol. 2013 Aug.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Patient lesions in January 2011, erythematous scaly plaques over 80% of her total body surface (SCORing atopic dermatitis [SCORAD]: 23).
Fig. 2
Fig. 2
Histopathologic findings of skin biopsy specimen from eczematous lesion before treatment, revealing features of subacute eczema with irregular acanthosis of epidermis, moderate spongiosis, and mixed cellular infiltrate of lymphocytes and histiocytes (H&E, ×100).
Fig. 3
Fig. 3
Absence of lesions in July 2011 (SCORing atopic dermatitis [SCORAD]: 0), 4 months after starting ustekinumab.

References

    1. Hu Y, Shen F, Crellin NK, Ouyang W. The IL-17 pathway as a major therapeutic target in autoimmune diseases. Ann N Y Acad Sci. 2011;1217:60–76. - PubMed
    1. Di Cesare A, Di Meglio P, Nestle FO. The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 2009;129:1339–1350. - PubMed
    1. Koga C, Kabashima K, Shiraishi N, Kobayashi M, Tokura Y. Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol. 2008;128:2625–2630. - PubMed
    1. Hayashida S, Uchi H, Moroi Y, Furue M. Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic dermatitis. J Dermatol Sci. 2011;61:180–186. - PubMed
    1. Puya R, Alvarez-López M, Velez A, Casas Asuncion E, Moreno JC. Treatment of severe refractory adult atopic dermatitis with ustekinumab. Int J Dermatol. 2012;51:115–116. - PubMed

LinkOut - more resources