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. 2013 Jun 1;10(1-2):21-25.
doi: 10.1016/j.ddmec.2013.03.006.

Obesity and metabolic inflammation

Haiyan Xu  1
Affiliations

Obesity and metabolic inflammation

Haiyan Xu. Drug Discov Today Dis Mech. .

Abstract

Obesity epidemics affect 35.7% of adults and approximately 17% of children in the United States. Obesity has been associated with several health disorders, such as type 2 diabetes, cardiovascular diseases, fatty liver disease, and certain forms of cancer. Medical costs associated with obesity were estimated at $147 billion in 2008. Chronic tissue inflammation, particularly in adipose tissue, has been considered as a key underlying mechanism for the development of obesity-related metabolic syndrome. In this review, we discuss the recent progress in the field of metabolic inflammation and the potential implication of anti-inflammation approaches as therapeutic interventions for treating obesity-related metabolic disorders.

Keywords: WAT; inflammation; obesity.

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Conflict of interest statement

Conflict of interest

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Illustration of adipose tissue expansion and associated changes of immune cell populations as well as the consequence on systemic insulin resistance. MDSC, myeloid-derived suppressor cell.
See this image and copyright information in PMC

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