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Case Reports
. 2013 Sep;33(5):383-5.
doi: 10.3343/alm.2013.33.5.383. Epub 2013 Aug 8.

The first case of septicemia caused by imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae

Shizuo Kayama  1 , Norifumi Shigemoto, Ryuichi Kuwahara, Takashi Ishino, Kentaro Imon, Makoto Onodera, Michiya Yokozaki, Hiroki Ohge, Motoyuki Sugai
Affiliations
Case Reports

The first case of septicemia caused by imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae

Shizuo Kayama et al. Ann Lab Med. 2013 Sep.
No abstract available

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Conflict of interest statement

No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Phenotypic detection of extended spectrum β-lactamase and carbapenemases in the K1 isolate, an imipenem-susceptible meropenem-resistant Klebsiella pneumoniae strain isolated from venous blood. (A) DDST with amoxicillin/clavulanate. K. pneumoniae K1 was inoculated onto the surface of a Muller-Hinton agar plate. Cephalosporin disks were applied at a distance of 20 mm from the clavulanate-containing disk; an enhanced zone of inhibition toward the clavulanate-containing disk was observed. (B) SMA test using IPM and MEM. K. pneumoniae K1 was inoculated onto the surface of a Muller-Hinton agar plate. An SMA disk was placed adjacent to either the IPM or MEM disk; an enhanced zone of inhibition toward the SMA disk was observed. (C) Modified Hodge test using IPM or MEM. E. coli ATCC25922 was inoculated onto the surface of a Muller-Hinton agar plate and organisms (K1, K5, K. pneumoniae ATCC BAA-1705 for positive control and K. pneumoniae ATCC BAA-1706 for negative control) were inoculated as streaks. Abbreviations: A/C, amoxicillin/clavulanate; CTX, cefotaxime; CPR, cefpirome; CAZ, ceftazidime; CFPM, cefepime; DDST, double-disk synergy test; IPM, imipenem; MEM, meropenem; SMA, sodium mercaptoacetic acid.
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References

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