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Comment
. 2013 Oct 15;19(20):5549-51.
doi: 10.1158/1078-0432.CCR-13-2117. Epub 2013 Sep 4.

Coamplification and cooperation: toward identifying biologically relevant oncogenes

Guochang Huang  1 , Bhuvanesh Singh
Affiliations
Comment

Coamplification and cooperation: toward identifying biologically relevant oncogenes

Guochang Huang et al. Clin Cancer Res. .

Abstract

Identification of biologically relevant genes from genomic assays is limited by the complexity of changes present in most solid tumors. Assessing for coactivation of functionally related genes resulted in the identification of SENP2, DCUN1D1, and DVL3--consensus candidates that drive selection for 3q amplification in lung squamous cell carcinomas.

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Conflict of interest statement

Conflict of interest statement: The authors have no conflicts of interest.

Figures

FIGURE
FIGURE
Analysis of results from TCGA showing abnormalities in DCUN1D1 family of genes in head and neck (154 of 295 cases; top panel) and lung (136 of 177 cases; bottom panel) squamous cell carcinomas showing both activating and inactivating alterations (data analysis was through the MSKCC cBio Portal for TCGA at http://cbio.mskcc.org/gdac-portal/).
See this image and copyright information in PMC

Comment on

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