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Case Reports
. 2013 Sep 4:2013:bcr2013200552.
doi: 10.1136/bcr-2013-200552.

Sarcoid panuveitis associated with etanercept treatment, resolving with adalimumab

D Dragnev  1 , D Barr, M Kulshrestha, S Shanmugalingam
Affiliations
Case Reports

Sarcoid panuveitis associated with etanercept treatment, resolving with adalimumab

D Dragnev et al. BMJ Case Rep. .

Abstract

We presented a case of a 54-year-old woman, who developed sarcoidosis uveitis while on treatment with the tumour necrosis factor α (TNFα) antagonist etanercept for rheumatoid arthritis. Her condition improved, but did not recover completely after the medication was stopped. After starting her on another TNFα antagonist, adalimumab, the uveitis recovered completely. Etanercept and adalimumab are from the same class of medication, but have different effects on other mediators and cells, which may explain these discrepancies.

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Figures

Figure 1
Figure 1
Right eye at presentation.
Figure 2
Figure 2
Right eye periphery at presentation.
Figure 3
Figure 3
Left eye at presentation.
Figure 4
Figure 4
Left eye periphery at presentation.
Figure 5
Figure 5
Visual field left eye at presentation.
Figure 6
Figure 6
CT scan of the chest.
Figure 7
Figure 7
Right eye after adalimumab treatment.
Figure 8
Figure 8
Right eye periphery after adalimumab treatment.
Figure 9
Figure 9
Left eye after adalimumab treatment.
Figure 10
Figure 10
Left eye periphery after adalimumab treatment.
See this image and copyright information in PMC

References

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    1. Gómez-Reino JJ, Carmona L, Valverde VR, et al. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: a multicentre active-surveillance report. Arthritis Rheum 2003;2013:2122–7 - PubMed
    1. Baughman RP, Strohofer SA, Buchsbaum J, et al. Release of tumor necrosis factor by alveolar macrophages of patients with sarcoidosis. J Lab Clin Med 1990;2013:36–42 - PubMed

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