[Current status and future perspectives of hepatocyte transplantation]

Abstract

The imbalance between the number of potential beneficiaries and available organs, originates the search for new therapeutic alternatives, such as Hepatocyte transplantation (HT).Even though this is a treatment option for these patients, the lack of unanimity of criteria regarding indications and technique, different cryopreservation protocols, as well as the different methodology to assess the response to this therapy, highlights the need of a Consensus Conference to standardize criteria and consider future strategies to improve the technique and optimize the results.Our aim is to review and update the current state of hepatocyte transplantation, emphasizing the future research attempting to solve the problems and improve the results of this treatment.

Keywords: Criopreservación; Cryopreservation; Células madre pluripotentes inducidas.; Células madre progenitoras; Errores congénitos del metabolismo; Hepatic cell transplantation; Inborn errors of metabolism; Induced pluripotent stem cells; Liver transplantation; Preacondicionamiento hepático; Preconditioning liver; Progenitor stem cell; Trasplante celular hepático; Trasplante hepático.