Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:7:1723-6.
doi: 10.2147/OPTH.S49350. Epub 2013 Aug 26.

Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy

Uri Soiberman  1 , Ran Levy, Igal Leibovitch
Affiliations

Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy

Uri Soiberman et al. Clin Ophthalmol. 2013.

Abstract

Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA.

Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls.

Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay.

Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20).

Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

Keywords: ELISA; Graves’ disease; Graves’ orbitopathy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mean adiponectin concentrations were mildly elevated in the study group in comparison to the control group. Standard deviations are depicted.
See this image and copyright information in PMC

References

    1. Bahn RS, Dutton CM, Natt N, Joba W, Spitzweg C, Heufelder AE. Thyrotropin receptor expression in Graves’ orbital adipose/connective tissues: potential autoantigen in Graves’ ophthalmopathy. J Clin Endocrinol Metab. 1998;83(3):998–1002. - PubMed
    1. Valyasevi RW, Erickson DZ, Harteneck DA, et al. Differentiation of human orbital preadipocyte fibroblasts induces expression of functional thyrotropin receptor. J Clin Endocrinol Metab. 1999;84(7):2557–2562. - PubMed
    1. Starkey KJ, Janezic A, Jones G, Jordan N, Baker G, Ludgate M. Adipose thyrotrophin receptor expression is elevated in Graves’ and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo. J Mol Endocrinol. 2003;30(3):369–380. - PubMed
    1. Krysiak R, Handzlik-Orlik G, Okopien B. The role of adipokines in connective tissue diseases. Eur J Nutr. 2012;51(5):513–528. - PMC - PubMed
    1. Kumar S, Leontovich A, Coenen MJ, Bahn RS. Gene expression profiling of orbital adipose tissue from patients with Graves’ ophthalmopathy: a potential role for secreted frizzled-related protein-1 in orbital adipogenesis. J Clin Endocrinol Metab. 2005;90(8):4730–4735. - PMC - PubMed

LinkOut - more resources