Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug 15:7:339.
doi: 10.3332/ecancer.2013.339. eCollection 2013.

Intraoperative radiotherapy with electrons: fundamentals, results, and innovation

Fa Calvo  1 , Cv Sole, R Herranz, M Lopez-Bote, J Pascau, A Santos, A Muñoz-Calero, C Ferrer, Jl Garcia-Sabrido
Affiliations

Intraoperative radiotherapy with electrons: fundamentals, results, and innovation

Fa Calvo et al. Ecancermedicalscience. .

Abstract

Rationale and objectives: To analyse the programme activity and clinical innovation and/or technology developed over a period of 17 years with regard to the introduction and the use of intraoperative radiotherapy (IORT) as a therapeutic component in a medical-surgical multidisciplinary cancer hospital.

Material and methods: To standardise and record this procedure, the Radiation Oncology service has an institutional programme and protocols that must be completed by the different specialists involved. For 17 years, IORT procedures were recorded on a specific database that includes 23 variables with information recorded on institutional protocols. As part of the development and innovation activity, two technological tools were implemented (RADIANCE and MEDTING) in line with the standardisation of this modality in clinical practice.

Results: During the 17 years studied, 1,004 patients were treated through 1,036 IORT procedures. The state of the disease at the time of IORT was 77% primary and 23% recurrent. The origin and distribution of cancers were 62% gastrointestinal, 18% sarcomas, 5% pancreatic, 2% paediatric, 3% breast, 7% less common locations, and 2% others. The research and development projects have generated a patent on virtual planning (RADIANCE) and proof of concept to explore as a professional social network (MEDTING). During 2012, there were 69 IORT procedures. There was defined treatment volume (target or target region) in all of them, and 43 were conducted by the virtual planning RADIANCE system. Eighteen have been registered on the platform MEDTING as clinical cases.

Conclusion: The IORT programme, developed in a university hospital with an academic tradition, and interdisciplinary surgical oncology, is a feasible care initiative, able to generate the necessary intense clinical activity for tending to the cancer patient. Moreover, it is a competitive source for research, development, and scientific innovation.

Keywords: MEDTING; RADIANCE; disease-free survival; global survival; innovative activity; intraoperative radiotherapy; multidisciplinary; standardisation.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:. Technical description HGUGM IORT.
Figure 2:
Figure 2:. Unmanned concept, planning, and pre-robotic automation IORT treatments.
Figure 3:
Figure 3:. IORT simulation using RADIANCE breast cancer.
Figure 4:
Figure 4:. IORT simulation unresectable pancreatic adenocarcinoma with RADIANCE.
Figure 5:
Figure 5:. MEDTING viewer: placement of images obtained from the medical history or surgical filming.
Figure 6:
Figure 6:. System filming and recording of images configured for automatic transfer MEDTING platform.
See this image and copyright information in PMC

References

    1. Calvo FA, Gonzalez-Domingo M, Usychin S. Intraoperative irradiation. In: Brady LW, Yaeger TE, editors. Encyclopedia of Radiation Oncology. Heidelberg: Springer; 2013. pp. 388–99.
    1. Gunderson LL, Willett CG, Calvo FA, Harrison LB. Rationale and historical perspective of intraoperative irradiation. In: Gunderson LL, Willett CG, Calvo FA, Harrison LB, editors. Intraoperative Irradiation. Techniques and Results. 2. Springer Heidelberg, Dordrecht, London, New York: Humana Press; 2011. pp. 3–26. - DOI
    1. Gunderson LL, Willett CG, Calvo FA, Harrison LB. Conclusions and future possibilities: IORT. In: Gunderson LL, Willett CG, Calvo FA, Harrison LB, editors. Intraoperative Irradiation. Techniques and Results. 2. Springer Heidelberg, Dordrecht, London, New York: Humana Press; 2011. pp. 503–18. - DOI
    1. Pascau J, Santos JA, Calvo FA, Bouché A, Morillo V, González-San Segundo C, et al. An innovative tool for electron beam radiotherapy intraoperative simulation and planning: description and initial evaluation by radiation oncologists. Int J Radiat Oncol Biol Phys. 2012;83(2):e287–95. - PubMed
    1. Calvo FA, Gomez-Espi M, Santos JA, Lozano MA, Herranz R, Lopez MA, et al. Hospital General. Vol. 1. Madrid: Gregorio Marañón General University Hospital; 2000. Intraoperative radiation therapy: methodological development and initial clinical experience; pp. 9–17.

LinkOut - more resources