doi: 10.1016/0006-8993(83)91238-6.
Estrogen responsiveness of progestin receptor induction in the pituitary, preoptic-hypothalamic brain and uterus of neonatally estrogenized female rats
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- PMID: 24010176
- DOI: 10.1016/0006-8993(83)91238-6
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Estrogen responsiveness of progestin receptor induction in the pituitary, preoptic-hypothalamic brain and uterus of neonatally estrogenized female rats
Brain Res.
.
Abstract
Female rats were defeminized by neonatal treatment with estradiol-17beta benzoate, moxestrol (RU 2858), monohydroxytamoxifen ICI 79,280) or the dibenzoate esters of the catecholestrogens, 2-hydroxyestradiol-17beta and 4-hydroxyestradiol-17beta. When ovariectomized as adults and primed with estradiol-17beta benzoate all these rats demonstrated a deficient luteinizing hormone response to progesterone administration. However, estrogen responsiveness of progestin receptor induction was unimpaired in both the pituitary gland, the preoptic-hypothalamic brain and the uterus.
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