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Review
. 2013 Nov;45(4):415-22.
doi: 10.3109/03602532.2013.835621. Epub 2013 Sep 6.

Sulfotransferase genetic variation: from cancer risk to treatment response

Jaclyn Daniels  1 , Susan Kadlubar
Affiliations
Review

Sulfotransferase genetic variation: from cancer risk to treatment response

Jaclyn Daniels et al. Drug Metab Rev. 2013 Nov.

Abstract

Cytosolic sulfotransferases (SULTs) are phase II detoxification enzymes that are involved in the biotransformation of a wide variety of structurally diverse endo- and xenobiotics. Single-nucleotide polymorphisms (SNPs) in SULTs can alter the phenotype of the translated proteins. SNPs in some SULTs are fairly uncommon in the population, but some, most notably for SULT isoform 1A1, are commonly found and have been associated with cancer risk for a variety of tumor sites and also with response to therapeutic agents. SNPs in many SULTs vary by ethnicity, another factor that could influence SULT-associated disease risk and pharmacogenetics. This review surveys the current knowledge of SULT genetic variability in relation to cancer risk and response to therapy, focusing primarily on SULT1A1.

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Conflict of interest statement

Declaration of interest

The authors declare no interests.

References

    1. Anderson RJ, Jackson BL. Human platelet phenol sulfotransferase: stability of two forms of the enzyme with time and presence of a racial difference. Clin Chim Acta. 1984;138:185–196. - PubMed
    1. Arlt VM, Glatt H, Muckel E, et al. Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. Carcinogenesis. 2002;23:1937–1945. - PubMed
    1. Arlt VM, Stiborova M, Henderson CJ, et al. Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. Cancer Res. 2005;65:2644–2652. - PubMed
    1. Arslan S. Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population. Biochem Genet. 2010;48:987–994. - PubMed
    1. Arslan S, Silig Y, Pinarbasi H. An investigation of the relationship between SULT1A1 Arg(213)His polymorphism and lung cancer susceptibility in a Turkish population. Cell Biochem Funct. 2009;27:211–215. - PubMed

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