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Comment
. 2013 Sep 3;18(3):309-11.
doi: 10.1016/j.cmet.2013.08.016.

Mrap2: an accessory protein linked to obesity

Tiemin Liu  1 , Joel K Elmquist, Kevin W Williams
Affiliations
Comment

Mrap2: an accessory protein linked to obesity

Tiemin Liu et al. Cell Metab. .

Abstract

Melanocortin receptors are critical modulators of energy balance and glucose homeostasis. Companion studies published in Science (Asai et al., 2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans.

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Figures

Figure 1
Figure 1. Role of Mrap2 in the regulation of central melanocortin receptors in zebrafish, mice and humans
(a) In zebrafish, Mrap2a inhibits, whereas Mrap2b stimulates, the activity of MC4 receptors (upper panel). In rodents, Mrap2 stimulates the activity of MC4 receptors (lower panel). (b) In humans, four rare heterozygous Mrap2 variants have been identified. Subjects carrying the E24X variant exhibit severe obesity, subjects with the two variants N88Y and R125C are moderately obese whereas subjects with the L115V variant display normal BMI.
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References

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